6NMW

Crystal structure of the human Lyn SH3 domain

6NMW の概要

• エントリーDOI: 10.2210/pdb6nmw/pdb
• 分子名称: Tyrosine-protein kinase Lyn (2 entities in total)
• 機能のキーワード: lyn kinase, src family kinase, non-receptor tyrosine kinase, sh3 domain, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8075.15

構造登録者

Berndt, S.,Gurevich, V.V.,Iverson, T.M. (登録日: 2019-01-12, 公開日: 2019-04-17, 最終更新日: 2023-10-11)

主引用文献

Berndt, S.,Gurevich, V.V.,Iverson, T.M.
Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.
PLoS ONE, 14:e0215140-e0215140, 2019

PubMed Abstract: Lyn kinase (Lck/Yes related novel protein tyrosine kinase) belongs to the family of Src-related non-receptor tyrosine kinases. Consistent with physiological roles in cell growth and proliferation, aberrant function of Lyn is associated with various forms of cancer, including leukemia, breast cancer and melanoma. Here, we determine a 1.3 Å resolution crystal structure of the polyproline-binding SH3 regulatory domain of human Lyn kinase, which adopts a five-stranded β-barrel fold. Mapping of cancer-associated point mutations onto this structure reveals that these amino acid substitutions are distributed throughout the SH3 domain and may affect Lyn kinase function distinctly.

PubMed: 30969999
DOI: 10.1371/journal.pone.0215140

実験手法

X-RAY DIFFRACTION (1.199 Å)