6NMU
Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
6NMU の概要
エントリーDOI | 10.2210/pdb6nmu/pdb |
関連するPDBエントリー | 6NMR 6NMS 6NMT |
分子名称 | Fab 115 anti-SIRP-alpha antibody Variable Light Chain, Fab 115 anti-SIRP-alpha antibody Variable Heavy Chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (4 entities in total) |
機能のキーワード | sirp-alpha, signal regulatory protein alpha, signal-regulatory protein alpha, tyrosine-protein phosphatase non-receptor type substrate 1, cd47, cluster of differentiation 47, anti-sirp-alpha antibody, blocking anti-sirp-alpha antibody, non-blocking anti-sirp-alpha antibody, kick-off anti-sirp-alpha antibody, anti-sirp-alpha antibody in complex with sirp-alpha, immune system |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 124061.93 |
構造登録者 | |
主引用文献 | Sim, J.,Sockolosky, J.T.,Sangalang, E.,Izquierdo, S.,Pedersen, D.,Harriman, W.,Wibowo, A.S.,Carter, J.,Madan, A.,Doyle, L.,Harrabi, O.,Kauder, S.E.,Chen, A.,Kuo, T.C.,Wan, H.,Pons, J. Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11:1036-1052, 2019 Cited by PubMed: 31257988DOI: 10.1080/19420862.2019.1624123 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.55 Å) |
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