6NKS
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP
Summary for 6NKS
Entry DOI | 10.2210/pdb6nks/pdb |
Descriptor | DNA polymerase beta, DNA (5'-D(P*GP*TP*CP*GP*G)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... (9 entities in total) |
Functional Keywords | dna polymerase beta, conformational change, enzyme mechanism, lfer, transcription, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48376.69 |
Authors | Batra, V.K.,Wilson, S.H. (deposition date: 2019-01-07, release date: 2020-01-08, Last modification date: 2024-03-13) |
Primary citation | Batra, V.K.,Alnajjar, K.S.,Sweasy, J.B.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H. Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59:955-963, 2020 Cited by PubMed: 31999437DOI: 10.1021/acs.biochem.9b01072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.349 Å) |
Structure validation
Download full validation report