6NJH

Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48

6NJH の概要

• エントリーDOI: 10.2210/pdb6njh/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pde4d, camp-specific 3'5'-cyclic phosphodiesterase 4d, ucr2, camp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 172251.00

構造登録者

Fox III, D.,Fairman, J.W.,Gurney, M.E. (登録日: 2019-01-03, 公開日: 2019-05-08, 最終更新日: 2024-03-13)

• 主引用文献: Gurney, M.E.,Nugent, R.A.,Mo, X.,Sindac, J.A.,Hagen, T.J.,Fox III, D.,O'Donnell, J.M.,Zhang, C.,Xu, Y.,Zhang, H.T.,Groppi, V.E.,Bailie, M.,White, R.E.,Romero, D.L.,Vellekoop, A.S.,Walker, J.R.,Surman, M.D.,Zhu, L.,Campbell, R.F.; Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.; J.Med.Chem., 62:4884-4901, 2019; PubMed: 31013090; DOI: 10.1021/acs.jmedchem.9b00193

実験手法

X-RAY DIFFRACTION (2.15 Å)