6NIG
Crystal structure of the human TLR2-Diprovocim complex
Summary for 6NIG
Entry DOI | 10.2210/pdb6nig/pdb |
Descriptor | Toll-like receptor 2,Variable lymphocyte receptor B, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de}, ... (5 entities in total) |
Functional Keywords | toll-like receptors, innate immune agonist, immune system-agonist complex, immune system/agonist |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 268435.38 |
Authors | Zhang, H.,Beutler, B.A.,Tomchick, D.R.,Su, L. (deposition date: 2018-12-27, release date: 2019-04-17, Last modification date: 2023-10-11) |
Primary citation | Su, L.,Wang, Y.,Wang, J.,Mifune, Y.,Morin, M.D.,Jones, B.T.,Moresco, E.M.Y.,Boger, D.L.,Beutler, B.,Zhang, H. Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. J. Med. Chem., 62:2938-2949, 2019 Cited by PubMed: 30829478DOI: 10.1021/acs.jmedchem.8b01583 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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