6NIG

Crystal structure of the human TLR2-Diprovocim complex

6NIG の概要

• エントリーDOI: 10.2210/pdb6nig/pdb
• 分子名称: Toll-like receptor 2,Variable lymphocyte receptor B, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de}, ... (5 entities in total)
• 機能のキーワード: toll-like receptors, innate immune agonist, immune system-agonist complex, immune system/agonist
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 268435.38

構造登録者

Zhang, H.,Beutler, B.A.,Tomchick, D.R.,Su, L. (登録日: 2018-12-27, 公開日: 2019-04-17, 最終更新日: 2023-10-11)

• 主引用文献: Su, L.,Wang, Y.,Wang, J.,Mifune, Y.,Morin, M.D.,Jones, B.T.,Moresco, E.M.Y.,Boger, D.L.,Beutler, B.,Zhang, H.; Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.; J. Med. Chem., 62:2938-2949, 2019; PubMed: 30829478; DOI: 10.1021/acs.jmedchem.8b01583

実験手法

X-RAY DIFFRACTION (2.35 Å)