6NHR

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45F mutant

6NHR の概要

• エントリーDOI: 10.2210/pdb6nhr/pdb
• 分子名称: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Influenza A virus (strain A/Hong Kong/1/1968 H3N2); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 171724.04

構造登録者

Wu, N.C.,Wilson, I.A. (登録日: 2018-12-23, 公開日: 2020-04-15, 最終更新日: 2024-11-20)

主引用文献

Wu, N.C.,Thompson, A.J.,Lee, J.M.,Su, W.,Arlian, B.M.,Xie, J.,Lerner, R.A.,Yen, H.L.,Bloom, J.D.,Wilson, I.A.
Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses.
Science, 368:1335-1340, 2020

PubMed Abstract: The discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem. Several strong resistance mutations in H3 can be observed in naturally circulating strains and do not reduce in vitro viral fitness and in vivo pathogenicity. This study highlights a potential challenge for development of a truly universal influenza vaccine.

PubMed: 32554590
DOI: 10.1126/science.aaz5143

実験手法

X-RAY DIFFRACTION (2.1 Å)