6NFA
Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
Summary for 6NFA
Entry DOI | 10.2210/pdb6nfa/pdb |
Related | 6NEW 6NF1 |
Descriptor | Proto-oncogene vav, ZINC ION, (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, ... (4 entities in total) |
Functional Keywords | gef, rac, vav1, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 50170.12 |
Authors | Knapp, M.S.,Elling, R.A.,Ornelas, E. (deposition date: 2018-12-19, release date: 2019-12-25, Last modification date: 2023-10-11) |
Primary citation | Gerspacher, M.,Skaanderup, P.R. Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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