6NEC

STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB

6NEC の概要

• エントリーDOI: 10.2210/pdb6nec/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase receptor Ret, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, FORMIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, oncogene, ret, tyrosine kinase, atp-binding, thyroid cancer, non-small cell lung cancer, nintedanib, complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72587.77

構造登録者

Terzyan, S.S.,Shen, T.,Wu, J.,Mooers, B.H.M. (登録日: 2018-12-17, 公開日: 2019-06-05, 最終更新日: 2023-10-11)

• 主引用文献: Terzyan, S.S.,Shen, T.,Liu, X.,Huang, Q.,Teng, P.,Zhou, M.,Hilberg, F.,Cai, J.,Mooers, B.H.M.,Wu, J.; Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.; J.Biol.Chem., 294:10428-10437, 2019; PubMed: 31118272; DOI: 10.1074/jbc.RA119.007682

実験手法

X-RAY DIFFRACTION (1.87 Å)