Designed repeat protein specifically in complex with Fz7CRD

Summary for 6NE4

DescriptorDesigned repeat binding protein, Frizzled-7, SULFATE ION, ... (5 entities in total)
Functional Keywordsfrizzled, designed protein, biosynthetic protein, biosynthetic protein-signaling protein complex, biosynthetic protein/signaling protein
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight36543.98
Miao, Y.,Jude, K.M.,Garcia, K.C. (deposition date: 2018-12-16, release date: 2019-05-15)
Primary citation
Dang, L.T.,Miao, Y.,Ha, A.,Yuki, K.,Park, K.,Janda, C.Y.,Jude, K.M.,Mohan, K.,Ha, N.,Vallon, M.,Yuan, J.,Vilches-Moure, J.G.,Kuo, C.J.,Garcia, K.C.,Baker, D.
Receptor subtype discrimination using extensive shape complementary designed interfaces
Nat.Struct.Mol.Biol., 2019
DOI: 10.1038/s41594-019-0224-z
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18730 1.2% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6ne4
no rotation
Molmil generated image of 6ne4
rotated about x axis by 90°
Molmil generated image of 6ne4
rotated about y axis by 90°