Crystal structure of HIV-1 broadly neutralizing antibody ACS202

Summary for 6NCP

Related6NC2 6NC3
EMDB information0433 0434
DescriptorACS202 Fab heavy chain, ACS202 Fab light chain, HIV-1 Fusion Peptide (residues 512-520), ... (7 entities in total)
Functional Keywordsantibody, hiv, envelope glycoprotein, fusion peptide, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight99449.4
Yuan, M.,Wilson, I.A. (deposition date: 2018-12-11, release date: 2019-06-19)
Primary citation
Yuan, M.,Cottrell, C.A.,Ozorowski, G.,van Gils, M.,Kumar, S.,Wu, N.C.,Sarkar, A.,Torres, J.L.,de Val, N.,Copps, J.,Moore, J.P.,Sanders, R.W.,Ward, A.B.,Wilson, I.A.
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies
Cell Host Microbe, 25:873-, 2019
DOI: 10.1016/j.chom.2019.04.011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2568 0.2% 1.6% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution