6NBH

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

Summary for 6NBH

• Entry DOI: 10.2210/pdb6nbh/pdb
• EMDB information: 0411
• Descriptor: Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ... (8 entities in total)
• Functional Keywords: parathyroid hormone receptor, gpcr, class b gpcr, gpcr-g protein complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 165860.57

Authors

Zhao, L.-H.,Ma, S.,Sutkeviciute, I.,Shen, D.-D.,Zhou, X.E.,de Waal, P.P.,Li, C.-Y.,Kang, Y.,Clark, L.J.,Jean-Alphonse, F.G.,White, A.D.,Xiao, K.,Yang, D.,Jiang, Y.,Watanabe, T.,Gardella, T.J.,Melcher, K.,Wang, M.-W.,Vilardaga, J.-P.,Xu, H.E.,Zhang, Y. (deposition date: 2018-12-07, release date: 2019-04-17, Last modification date: 2019-12-18)

• Primary citation: Zhao, L.H.,Ma, S.,Sutkeviciute, I.,Shen, D.D.,Zhou, X.E.,de Waal, P.W.,Li, C.Y.,Kang, Y.,Clark, L.J.,Jean-Alphonse, F.G.,White, A.D.,Yang, D.,Dai, A.,Cai, X.,Chen, J.,Li, C.,Jiang, Y.,Watanabe, T.,Gardella, T.J.,Melcher, K.,Wang, M.W.,Vilardaga, J.P.,Xu, H.E.,Zhang, Y.; Structure and dynamics of the active human parathyroid hormone receptor-1.; Science, 364:148-153, 2019; PubMed: 30975883; DOI: 10.1126/science.aav7942

Experimental method

ELECTRON MICROSCOPY (3.5 Å)