6N9F

Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution

This is a non-PDB format compatible entry.

Summary for 6N9F

• Entry DOI: 10.2210/pdb6n9f/pdb
• Descriptor: 23S Ribosomal RNA, 50S Ribosomal Protein L14, 50S Ribosomal Protein L15, ... (59 entities in total)
• Functional Keywords: d-amino acids, ribosome structure, peptidyl transferase center, expanded genetic code, ribosome engineering, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 110
• Total formula weight: 4439064.75

Authors

Melnikov, S.V.,Khabibullina, N.F.,Mairhofer, E.,Vargas-Rodriguez, O.,Reynolds, N.M.,Micura, R.,Soll, D.,Polikanov, Y.S. (deposition date: 2018-12-03, release date: 2018-12-12, Last modification date: 2023-11-15)

• Primary citation: Melnikov, S.V.,Khabibullina, N.F.,Mairhofer, E.,Vargas-Rodriguez, O.,Reynolds, N.M.,Micura, R.,Soll, D.,Polikanov, Y.S.; Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.; Nucleic Acids Res., 47:2089-2100, 2019; PubMed: 30520988; DOI: 10.1093/nar/gky1211

Experimental method

X-RAY DIFFRACTION (3.7 Å)