6N9F

Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution

これは巨大構造です。

6N9F の概要

分子名称23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... (59 entities in total)
機能のキーワードd-amino acids, ribosome structure, peptidyl transferase center, expanded genetic code, ribosome engineering, ribosome
由来する生物種Escherichia coli
詳細
ポリマー鎖数110
分子量合計4439064.75
構造登録者
Melnikov, S.V.,Khabibullina, N.F.,Mairhofer, E.,Vargas-Rodriguez, O.,Reynolds, N.M.,Micura, R.,Soll, D.,Polikanov, Y.S. (登録日: 2018-12-03, 公開日: 2018-12-12, 最終更新日: 2020-01-01)
主引用文献
Melnikov, S.V.,Khabibullina, N.F.,Mairhofer, E.,Vargas-Rodriguez, O.,Reynolds, N.M.,Micura, R.,Soll, D.,Polikanov, Y.S.
Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47:2089-2100, 2019
PubMed: 30520988 (主引用文献が同じPDBエントリー)
DOI: 10.1093/nar/gky1211
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.7 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone 0.27910 0.6% 0.6% 8.2% 0.57MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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