6N92

Methylmalonyl-CoA decarboxylase in complex with 2-nitronate-propionyl-CoA

Summary for 6N92

• Entry DOI: 10.2210/pdb6n92/pdb
• Related: 1EF8 1EF9
• Descriptor: Methylmalonyl-CoA decarboxylase, [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium, NICKEL (II) ION, ... (8 entities in total)
• Functional Keywords: crotonase, beta-keto, isostere, lyase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 6
• Total formula weight: 183602.27

Authors

Stunkard, L.M.,Dixon, A.D.,Huth, T.J.,Lohman, J.R. (deposition date: 2018-11-30, release date: 2019-04-10, Last modification date: 2023-10-11)

• Primary citation: Stunkard, L.M.,Dixon, A.D.,Huth, T.J.,Lohman, J.R.; Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Methylmalonyl-CoA Decarboxylase Structure-Function Studies.; J. Am. Chem. Soc., 141:5121-5124, 2019; PubMed: 30869886; DOI: 10.1021/jacs.9b00650

Experimental method

X-RAY DIFFRACTION (1.7 Å)