6N80
S. aureus ClpP bound to anti-4a
Summary for 6N80
Entry DOI | 10.2210/pdb6n80/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, N-[(1R)-1-borono-3-methylbutyl]-N~2~-(2-chloro-4-methoxybenzene-1-carbonyl)-L-leucinamide (3 entities in total) |
Functional Keywords | clpp, hydrolase |
Biological source | Staphylococcus aureus (strain NCTC 8325) |
Total number of polymer chains | 14 |
Total formula weight | 322285.63 |
Authors | Lee, R.E.,Griffith, E.C. (deposition date: 2018-11-28, release date: 2019-06-26, Last modification date: 2019-12-18) |
Primary citation | Tan, J.,Grouleff, J.J.,Jitkova, Y.,Diaz, D.B.,Griffith, E.C.,Shao, W.,Bogdanchikova, A.F.,Poda, G.,Schimmer, A.D.,Lee, R.E.,Yudin, A.K. De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX. J.Med.Chem., 62:6377-6390, 2019 Cited by PubMed: 31187989DOI: 10.1021/acs.jmedchem.9b00878 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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