6N7A
Structure of the human JAK1 kinase domain with compound 39
Summary for 6N7A
Entry DOI | 10.2210/pdb6n7a/pdb |
Descriptor | Tyrosine-protein kinase JAK1, GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, ... (4 entities in total) |
Functional Keywords | jak1, il13, il-13, jak2, jak3, tyk2, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70851.39 |
Authors | Lupardus, P.J.,Brown, D. (deposition date: 2018-11-27, release date: 2019-04-24, Last modification date: 2019-05-15) |
Primary citation | Zak, M.,Hanan, E.J.,Lupardus, P.,Brown, D.G.,Robinson, C.,Siu, M.,Lyssikatos, J.P.,Romero, F.A.,Zhao, G.,Kellar, T.,Mendonca, R.,Ray, N.C.,Goodacre, S.C.,Crackett, P.H.,McLean, N.,Hurley, C.A.,Yuen, P.W.,Cheng, Y.X.,Liu, X.,Liimatta, M.,Kohli, P.B.,Nonomiya, J.,Salmon, G.,Buckley, G.,Lloyd, J.,Gibbons, P.,Ghilardi, N.,Kenny, J.R.,Johnson, A. Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29:1522-1531, 2019 Cited by PubMed: 30981576DOI: 10.1016/j.bmcl.2019.04.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.33 Å) |
Structure validation
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