6N7A
Structure of the human JAK1 kinase domain with compound 39
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK1 | polymer | 304 | 34890.7 | 2 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
| 2 | C, D, F (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | E, G (A, B) | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide | non-polymer | 396.8 | 2 | Chemie (KEV) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 588 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 851 | - | expression tag |
| Ser 852 | - | expression tag |
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69781.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1069.9 | |
| All* | Total formula weight | 70851.4 |
