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6N4R

CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2

Summary for 6N4R
Entry DOI10.2210/pdb6n4r/pdb
EMDB information0342
DescriptorNav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ... (4 entities in total)
Functional Keywordsvoltage-gated sodium channel, gating modifier toxin, membrane protein
Biological sourceArcobacter butzleri (strain RM4018)
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Total number of polymer chains12
Total formula weight245187.65
Authors
Xu, H.,Rohou, A.,Arthur, C.P.,Estevez, A.,Ciferri, C.,Payandeh, J.,Koth, C.M. (deposition date: 2018-11-20, release date: 2019-01-23, Last modification date: 2019-12-18)
Primary citationXu, H.,Li, T.,Rohou, A.,Arthur, C.P.,Tzakoniati, F.,Wong, E.,Estevez, A.,Kugel, C.,Franke, Y.,Chen, J.,Ciferri, C.,Hackos, D.H.,Koth, C.M.,Payandeh, J.
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176:702-, 2019
Cited by
PubMed: 30661758
DOI: 10.1016/j.cell.2018.12.018
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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