6N4I
Structural basis of Nav1.7 inhibition by a gating-modifier spider toxin
Summary for 6N4I
Entry DOI | 10.2210/pdb6n4i/pdb |
Descriptor | Nav1.7 VSD2-NavAb channel chimera protein, Beta/omega-theraphotoxin-Tp2a, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate (3 entities in total) |
Functional Keywords | sodium channel, toxin, gating-modifier, voltage-gated, metal transport |
Biological source | Homo sapiens More |
Total number of polymer chains | 8 |
Total formula weight | 160660.73 |
Authors | Xu, H.,Koth, C.M.,Payandeh, J. (deposition date: 2018-11-19, release date: 2019-01-23, Last modification date: 2023-10-11) |
Primary citation | Xu, H.,Li, T.,Rohou, A.,Arthur, C.P.,Tzakoniati, F.,Wong, E.,Estevez, A.,Kugel, C.,Franke, Y.,Chen, J.,Ciferri, C.,Hackos, D.H.,Koth, C.M.,Payandeh, J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176:702-715.e14, 2019 Cited by PubMed: 30661758DOI: 10.1016/j.cell.2018.12.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.541 Å) |
Structure validation
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