6N2T
Ternary complex crystal structure of DNA polymerase Beta with 5-hydroxymethyl-dC (5-hmC) at the templating position
Summary for 6N2T
Entry DOI | 10.2210/pdb6n2t/pdb |
Descriptor | DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(5HC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (8 entities in total) |
Functional Keywords | dna polymerase beta, conformational change, enzyme mechanism, epigenetic modifications, transferase-dna complex, gene regulation-dna complex, gene regulation/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48297.67 |
Authors | Batra, V.K.,Wilson, S.H. (deposition date: 2018-11-14, release date: 2019-03-27, Last modification date: 2023-10-11) |
Primary citation | Howard, M.J.,Foley, K.G.,Shock, D.D.,Batra, V.K.,Wilson, S.H. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase beta. J.Biol.Chem., 294:7194-7201, 2019 Cited by PubMed: 30885943DOI: 10.1074/jbc.RA118.006809 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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