6N2T

Ternary complex crystal structure of DNA polymerase Beta with 5-hydroxymethyl-dC (5-hmC) at the templating position

Summary for 6N2T

• Entry DOI: 10.2210/pdb6n2t/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(5HC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (8 entities in total)
• Functional Keywords: dna polymerase beta, conformational change, enzyme mechanism, epigenetic modifications, transferase-dna complex, gene regulation-dna complex, gene regulation/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48297.67

Authors

Batra, V.K.,Wilson, S.H. (deposition date: 2018-11-14, release date: 2019-03-27, Last modification date: 2023-10-11)

• Primary citation: Howard, M.J.,Foley, K.G.,Shock, D.D.,Batra, V.K.,Wilson, S.H.; Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase beta.; J.Biol.Chem., 294:7194-7201, 2019; PubMed: 30885943; DOI: 10.1074/jbc.RA118.006809

Experimental method

X-RAY DIFFRACTION (2.6 Å)