6N2M

NMR solution structure of the homodimeric, autoinhibited state of the CARD9 CARD and first coiled-coil

Summary for 6N2M

• Entry DOI: 10.2210/pdb6n2m/pdb
• Related: 6N2P
• NMR Information: BMRB: 30543
• Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION (2 entities in total)
• Functional Keywords: innate immunity, coiled-coil, autoinhibition, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32363.73

Authors

Holliday, M.J.,Fairbrother, W.J.,Dueber, E.C. (deposition date: 2018-11-13, release date: 2019-07-17, Last modification date: 2023-06-14)

• Primary citation: Holliday, M.J.,Witt, A.,Rodriguez Gama, A.,Walters, B.T.,Arthur, C.P.,Halfmann, R.,Rohou, A.,Dueber, E.C.,Fairbrother, W.J.; Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.; Nat Commun, 10:3070-3070, 2019; PubMed: 31296852; DOI: 10.1038/s41467-019-10953-z

Experimental method

SOLUTION NMR