6MXZ

Structure of 53BP1 Tudor domains in complex with small molecule UNC3474

6MXZ の概要

• エントリーDOI: 10.2210/pdb6mxz/pdb
• 分子名称: TP53-binding protein 1, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, FORMIC ACID, ... (4 entities in total)
• 機能のキーワード: dna damage response, tudor domain, 53bp1, small molecule inhibitor, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 141152.06

構造登録者

Cui, G.,Botuyan, M.V.,Schuller, D.J.,Mer, G. (登録日: 2018-10-31, 公開日: 2019-11-27, 最終更新日: 2023-10-11)

• 主引用文献: Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G.; An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.; Nat Commun, 14:6091-6091, 2023; PubMed: 37773238; DOI: 10.1038/s41467-023-41821-6

実験手法

X-RAY DIFFRACTION (2.5 Å)