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6MXR

Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M]

Summary for 6MXR
Entry DOI10.2210/pdb6mxr/pdb
Related6MXS 6MY4 6MY5
Descriptoranti-VEGF-A Fab fragment bH1 heavy chain, anti-VEGF-A Fab fragment bH1 light chain, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsfab fragment, antibody self-assembly, aggregation, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight98914.18
Authors
Shi, R. (deposition date: 2018-10-31, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citationSchrag, J.D.,Picard, M.E.,Gaudreault, F.,Gagnon, L.P.,Baardsnes, J.,Manenda, M.S.,Sheff, J.,Deprez, C.,Baptista, C.,Hogues, H.,Kelly, J.F.,Purisima, E.O.,Shi, R.,Sulea, T.
Binding symmetry and surface flexibility mediate antibody self-association.
Mabs, 11:1300-1318, 2019
Cited by
PubMed: 31318308
DOI: 10.1080/19420862.2019.1632114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

221051

건을2024-06-12부터공개중

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