6MXR

Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M]

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, A)	anti-VEGF-A Fab fragment bH1 heavy chain	polymer	236	25422.5	2	UniProt (V9HW68) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
2	B, D (L, B)	anti-VEGF-A Fab fragment bH1 light chain	polymer	218	23956.6	2	UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	E, H (L, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	F (L)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	G (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	I, J, K, L (H, L, A, B)	water	water		18.0	722	Chemie (HOH)

Sequence modifications

H, A: 1 - 102 (PDB: 6MXR)
H, A: 103 - 219 (UniProt: V9HW68)

PDB	External Database	Details
Gly 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
Gly 229	-	expression tag

L, B: 1 - 104 (PDB: 6MXR)
L, B: 105 - 214 (UniProt: Q7Z3Y4)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	98758.2
Non-Polymers*	Number of molecules	4
	Total formula weight	156.0
All*	Total formula weight	98914.2

*Water molecules are not included.