6MXR
Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M]
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, A | anti-VEGF-A Fab fragment bH1 heavy chain | polymer | 236 | 25422.5 | 2 | UniProt (V9HW68) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
2 | L, B | anti-VEGF-A Fab fragment bH1 light chain | polymer | 218 | 23956.6 | 2 | UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | L, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
4 | L | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
6 | water | water | 18.0 | 722 | Chemie (HOH) |
Sequence modifications
H, A: 1 - 102 (PDB: 6MXR)
H, A: 103 - 219 (UniProt: V9HW68)
L, B: 1 - 104 (PDB: 6MXR)
L, B: 105 - 214 (UniProt: Q7Z3Y4)
H, A: 103 - 219 (UniProt: V9HW68)
PDB | External Database | Details |
---|---|---|
Gly 220 | - | expression tag |
His 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
His 225 | - | expression tag |
His 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
Gly 229 | - | expression tag |
L, B: 105 - 214 (UniProt: Q7Z3Y4)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 98758.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 156.0 | |
All* | Total formula weight | 98914.2 |