6MXE

Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18

6MXE の概要

• エントリーDOI: 10.2210/pdb6mxe/pdb
• 分子名称: Stimulator of interferon genes protein, [(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: innate immunity, signaling, open conformation, immune system, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44184.45

構造登録者

Lesburg, C.A.,Siu, T.,Ho, T. (登録日: 2018-10-30, 公開日: 2018-12-19, 最終更新日: 2024-03-13)

• 主引用文献: Siu, T.,Altman, M.D.,Baltus, G.A.,Childers, M.,Ellis, J.M.,Gunaydin, H.,Hatch, H.,Ho, T.,Jewell, J.,Lacey, B.M.,Lesburg, C.A.,Pan, B.S.,Sauvagnat, B.,Schroeder, G.K.,Xu, S.; Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.; ACS Med Chem Lett, 10:92-97, 2019; PubMed: 30655953; DOI: 10.1021/acsmedchemlett.8b00466

実験手法

X-RAY DIFFRACTION (2.47 Å)