6MVD

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator

「6DTJ」から置き換えられました

6MVD の概要

• エントリーDOI: 10.2210/pdb6mvd/pdb
• 分子名称: Phosphatidylcholine-sterol acyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose, propan-2-yl hydrogen (R)-ethylphosphonate, ... (7 entities in total)
• 機能のキーワード: lcat, acyltransferase, cholesterol, activator, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90375.54

構造登録者

Manthei, K.A.,Chang, L.,Tesmer, J.J.G. (登録日: 2018-10-25, 公開日: 2018-12-05, 最終更新日: 2023-10-11)

• 主引用文献: Manthei, K.A.,Yang, S.M.,Baljinnyam, B.,Chang, L.,Glukhova, A.,Yuan, W.,Freeman, L.A.,Maloney, D.J.,Schwendeman, A.,Remaley, A.T.,Jadhav, A.,Tesmer, J.J.; Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.; Elife, 7:-, 2018; PubMed: 30479275; DOI: 10.7554/eLife.41604

実験手法

X-RAY DIFFRACTION (3.1 Å)