6MV5

Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9 (E32K)

Summary for 6MV5

• Entry DOI: 10.2210/pdb6mv5/pdb
• Related: 6E4Y 6E4Z
• Descriptor: Anti-PCSK9 fab 6E2 heavy chain, Anti-PCSK9 fab 6E2 light chain, Proprotein convertase subtilisin/kexin type 9, ... (7 entities in total)
• Functional Keywords: antibody, hydrolase, pcsk9, fab complex, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 51279.93

Authors

Ultsch, M.H.,Kirchhofer, D.K. (deposition date: 2018-10-24, release date: 2019-04-10, Last modification date: 2023-10-11)

• Primary citation: Ultsch, M.,Li, W.,Eigenbrot, C.,Di Lello, P.,Lipari, M.T.,Gerhardy, S.,AhYoung, A.P.,Quinn, J.,Franke, Y.,Chen, Y.,Kong Beltran, M.,Peterson, A.,Kirchhofer, D.; Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain.; J. Mol. Biol., 431:885-903, 2019; PubMed: 30653992; DOI: 10.1016/j.jmb.2018.11.025

Experimental method

X-RAY DIFFRACTION (2.1 Å)