6MV5

Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9 (E32K)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Anti-PCSK9 fab 6E2 heavy chain	polymer	224	24255.2	1		Mus musculus (Mouse)
2	L	Anti-PCSK9 fab 6E2 light chain	polymer	219	24040.9	1	UniProt (A0A097PUG4) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (Mouse)
3	P	Proprotein convertase subtilisin/kexin type 9	polymer	23	2494.6	1	UniProt (Q8NBP7) In PDB	Homo sapiens	Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9
4	H, L	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	H	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	H, L	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7		water	water		18.0	143	Chemie (HOH)

Sequence modifications

L: 1 - 106 (PDB: 6MV5)
L: 107 - 214 (UniProt: A0A097PUG4)
P: 32 - 53 (UniProt: Q8NBP7)

PDB	External Database	Details
Ace 1	-	acetylation
Lys 32	Glu 32	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	50790.7
Non-Polymers*	Number of molecules	7
	Total formula weight	489.2
All*	Total formula weight	51279.9

*Water molecules are not included.