6MUF

Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.4 Angstrom

6MUF の概要

• エントリーDOI: 10.2210/pdb6muf/pdb
• 関連するPDBエントリー: 6MTJ
• 分子名称: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: hiv-1 envelope prefusion trimer, entry inhibitors, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 155442.52

構造登録者

Lai, Y.-T.,Kwong, P.D. (登録日: 2018-10-23, 公開日: 2019-01-16, 最終更新日: 2020-07-29)

• 主引用文献: Lai, Y.T.,Wang, T.,O'Dell, S.,Louder, M.K.,Schon, A.,Cheung, C.S.F.,Chuang, G.Y.,Druz, A.,Lin, B.,McKee, K.,Peng, D.,Yang, Y.,Zhang, B.,Herschhorn, A.,Sodroski, J.,Bailer, R.T.,Doria-Rose, N.A.,Mascola, J.R.,Langley, D.R.,Kwong, P.D.; Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.; Nat Commun, 10:47-47, 2019; PubMed: 30604750; DOI: 10.1038/s41467-018-07851-1

実験手法

X-RAY DIFFRACTION (2.91 Å)