6MR5
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor
Summary for 6MR5
Entry DOI | 10.2210/pdb6mr5/pdb |
Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (8 entities in total) |
Functional Keywords | histone deacetylase, zinc hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 82012.16 |
Authors | Porter, N.J.,Christianson, D.W. (deposition date: 2018-10-11, release date: 2018-12-05, Last modification date: 2024-03-13) |
Primary citation | Porter, N.J.,Shen, S.,Barinka, C.,Kozikowski, A.P.,Christianson, D.W. Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. ACS Med Chem Lett, 9:1301-1305, 2018 Cited by PubMed: 30613344DOI: 10.1021/acsmedchemlett.8b00487 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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