6MR5

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor

6MR5 の概要

• エントリーDOI: 10.2210/pdb6mr5/pdb
• 分子名称: Hdac6 protein, ZINC ION, POTASSIUM ION, ... (8 entities in total)
• 機能のキーワード: histone deacetylase, zinc hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82012.16

構造登録者

Porter, N.J.,Christianson, D.W. (登録日: 2018-10-11, 公開日: 2018-12-05, 最終更新日: 2024-03-13)

• 主引用文献: Porter, N.J.,Shen, S.,Barinka, C.,Kozikowski, A.P.,Christianson, D.W.; Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.; ACS Med Chem Lett, 9:1301-1305, 2018; PubMed: 30613344; DOI: 10.1021/acsmedchemlett.8b00487

実験手法

X-RAY DIFFRACTION (1.85 Å)