6MOM

Crystal structure of human Interleukin-1 receptor associated Kinase 4 (IRAK 4, CID 100300) in complex with compound NCC00371481 (BSI 107591)

Summary for 6MOM

• Entry DOI: 10.2210/pdb6mom/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, 6-[7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-N-[(3R)-pyrrolidin-3-yl]pyridin-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: interleukin-1 receptor associated kinase 4, cid 100300, ncc00371481, bsi 107591, beryllium, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 138083.23

Authors

Abendroth, J.,Mayclin, S.J.,Lorimer, D.D.,Starczynowski, D.,Hoyt, S.,Tawa, G.,Thomas, C. (deposition date: 2018-10-04, release date: 2019-10-16, Last modification date: 2023-10-11)

• Primary citation: Melgar, K.,Walker, M.M.,Jones, L.M.,Bolanos, L.C.,Hueneman, K.,Wunderlich, M.,Jiang, J.K.,Wilson, K.M.,Zhang, X.,Sutter, P.,Wang, A.,Xu, X.,Choi, K.,Tawa, G.,Lorimer, D.,Abendroth, J.,O'Brien, E.,Hoyt, S.B.,Berman, E.,Famulare, C.A.,Mulloy, J.C.,Levine, R.L.,Perentesis, J.P.,Thomas, C.J.,Starczynowski, D.T.; Overcoming adaptive therapy resistance in AML by targeting immune response pathways.; Sci Transl Med, 11:-, 2019; PubMed: 31484791; DOI: 10.1126/scitranslmed.aaw8828

Experimental method

X-RAY DIFFRACTION (2.1 Å)