6MNE

CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE AND NADP+

Summary for 6MNE

• Entry DOI: 10.2210/pdb6mne/pdb
• Descriptor: Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (5 entities in total)
• Functional Keywords: 17beta-hsd1, estrone, functional analyses, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72097.64

Authors

Li, T.,Lin, S.X. (deposition date: 2018-10-01, release date: 2019-04-03, Last modification date: 2023-10-11)

• Primary citation: Li, T.,Stephen, P.,Zhu, D.W.,Shi, R.,Lin, S.X.; Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.; Febs J., 286:2155-2166, 2019; PubMed: 30768851; DOI: 10.1111/febs.14784

Experimental method

X-RAY DIFFRACTION (1.86 Å)