6MN2

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA

6MN2 の概要

• エントリーDOI: 10.2210/pdb6mn2/pdb
• 関連するPDBエントリー: 5TH0
• 分子名称: Aminoglycoside N(3)-acetyltransferase, COENZYME A, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, ... (7 entities in total)
• 機能のキーワード: antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, coenzyme a, sisomicin, csgid, transferase, center for structural genomics of infectious diseases, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: uncultured bacterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60153.48

構造登録者

Stogios, P.J.,Skarina, T.,Michalska, K.,Xu, Z.,Yim, V.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2018-10-01, 公開日: 2018-10-24, 最終更新日: 2023-10-11)

• 主引用文献: Stogios, P.J.; Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA; To Be Published,

実験手法

X-RAY DIFFRACTION (2.744 Å)