6MK0

Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161

Summary for 6MK0

• Entry DOI: 10.2210/pdb6mk0/pdb
• Descriptor: Integrin alpha-V, Integrin beta-3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hybrid domain, psi, egf repeats, beta tail, calf, thigh, beta propeller, rgd motif, fibronectin, vitronectin, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 187642.26

Authors

van Agthoven, J.,Arnaout, M.A. (deposition date: 2018-09-24, release date: 2019-09-25, Last modification date: 2023-10-11)

• Primary citation: Li, J.,Fukase, Y.,Shang, Y.,Zou, W.,Munoz-Felix, J.,Buitrago, L.,van Agthoven, J.,Zhang, Y.,Hara, R.,Tanaka, Y.,Okamoto, R.,Yasui, T.,Nakahata, T.,Imaeda, T.,Aso, K.,Zhou, Y.,Locuson, C.,Nesic, D.,Duggan, M.,Takagi, J.,Vaughan, R.D.,Walz, T.,Hodivala-Dilke, K.,Teitelbaum, S.L.,Arnaout, M.A.,Filizola, M.,Foley, M.A.,Coller, B.S.; Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations; Acs Pharmacol Transl Sci, 2:387-401, 2019; DOI: 10.1021/acsptsci.9b00041

Experimental method

X-RAY DIFFRACTION (3.005 Å)