6MK0
Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Integrin alpha-V | polymer | 954 | 105541.8 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) In PDB | Homo sapiens (Human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B | Integrin beta-3 | polymer | 687 | 76042.7 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (Human) | Platelet membrane glycoprotein IIIa,GPIIIa |
| 3 | C, E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D | alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G93290PO) | |||
| 5 | H | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 7 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 8 | Chemie (MN) | |||
| 8 | B | (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid | non-polymer | 491.6 | 1 | Chemie (JUY) | |||
| 9 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 181584.4 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3357.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2700.7 | |
| All* | Total formula weight | 187642.3 |
