6MHG

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

6MHG の概要

• エントリーDOI: 10.2210/pdb6mhg/pdb
• EMDBエントリー: 9114
• 分子名称: circumsporozoite protein, Fab311 heavy chain, Fab311 light chain (3 entities in total)
• 機能のキーワード: plasmodium falciparum, antibody, csp, rscsp, immune system
• 由来する生物種: Plasmodium falciparum; 詳細
• タンパク質・核酸の鎖数: 23
• 化学式量合計: 548105.13

構造登録者

Cottrell, C.A.,Torres, J.L.,Ward, A.B. (登録日: 2018-09-17, 公開日: 2018-10-31)

• 主引用文献: Oyen, D.,Torres, J.L.,Cottrell, C.A.,Richter King, C.,Wilson, I.A.,Ward, A.B.; Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.; Sci Adv, 4:eaau8529-eaau8529, 2018; PubMed: 30324137; DOI: 10.1126/sciadv.aau8529

実験手法

ELECTRON MICROSCOPY (3.57 Å)