6MGQ

ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014

6MGQ の概要

• エントリーDOI: 10.2210/pdb6mgq/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002326
• 分子名称: Endoplasmic reticulum aminopeptidase 1, Phosphinic inhibitor DG014, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: inhibitor, aminopeptidase, immune system, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 332958.36

構造登録者

Stern, L.J.,Maben, Z. (登録日: 2018-09-14, 公開日: 2019-12-18, 最終更新日: 2023-10-11)

• 主引用文献: Maben, Z.,Arya, R.,Georgiadis, D.,Stratikos, E.,Stern, L.J.; Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.; Nat Commun, 12:5302-5302, 2021; PubMed: 34489420; DOI: 10.1038/s41467-021-25564-w

実験手法

X-RAY DIFFRACTION (2.92 Å)