6MG5

Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1

6MG5 の概要

• エントリーDOI: 10.2210/pdb6mg5/pdb
• 分子名称: Light chain JTO, PHOSPHATE ION, 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, ... (4 entities in total)
• 機能のキーワード: light chain, amyloidosis, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47280.87

構造登録者

Morgan, G.J.,Yan, N.L.,Mortenson, D.E.,Stanfield, R.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2018-09-12, 公開日: 2019-04-10, 最終更新日: 2019-12-25)

• 主引用文献: Morgan, G.J.,Yan, N.L.,Mortenson, D.E.,Rennella, E.,Blundon, J.M.,Gwin, R.M.,Lin, C.Y.,Stanfield, R.L.,Brown, S.J.,Rosen, H.,Spicer, T.P.,Fernandez-Vega, V.,Merlini, G.,Kay, L.E.,Wilson, I.A.,Kelly, J.W.; Stabilization of amyloidogenic immunoglobulin light chains by small molecules.; Proc.Natl.Acad.Sci.USA, 116:8360-8369, 2019; PubMed: 30971495; DOI: 10.1073/pnas.1817567116

実験手法

X-RAY DIFFRACTION (1.8 Å)