6MFX

Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state

Summary for 6MFX

Entry DOI	10.2210/pdb6mfx/pdb
Descriptor	Linear gramicidin synthase subunit A, N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (5 entities in total)
Functional Keywords	nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase
Biological source	Brevibacillus parabrevis
Total number of polymer chains	1
Total formula weight	138960.85
Authors	Reimer, J.M.,Eivaskhani, M.,Schmeing, T.M. (deposition date: 2018-09-12, release date: 2019-11-20, Last modification date: 2023-10-11)
Primary citation	Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366:-, 2019 Cited by PubMed: 31699907 DOI: 10.1126/science.aaw4388 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation