6MFX

Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state

6MFX の概要

• エントリーDOI: 10.2210/pdb6mfx/pdb
• 分子名称: Linear gramicidin synthase subunit A, N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (5 entities in total)
• 機能のキーワード: nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase
• 由来する生物種: Brevibacillus parabrevis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 138960.85

構造登録者

Reimer, J.M.,Eivaskhani, M.,Schmeing, T.M. (登録日: 2018-09-12, 公開日: 2019-11-20, 最終更新日: 2023-10-11)

• 主引用文献: Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M.; Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.; Science, 366:-, 2019; PubMed: 31699907; DOI: 10.1126/science.aaw4388

実験手法

X-RAY DIFFRACTION (2.2 Å)