6MEI

Crystal structure of broadly neutralizing antibody HEPC3 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

6MEI の概要

• エントリーDOI: 10.2210/pdb6mei/pdb
• 分子名称: E2 glycoprotein, antibody HEPC3 Heavy Chain, antibody HEPC3 Light Chain, ... (8 entities in total)
• 機能のキーワード: hcv glycoprotein, broadly neutralizing antibodies, immune system
• 由来する生物種: Hepacivirus C; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 82353.10

構造登録者

Flyak, A.I.,Bjorkman, P.J. (登録日: 2018-09-06, 公開日: 2018-11-21, 最終更新日: 2020-07-29)

• 主引用文献: Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J.; HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.; Cell Host Microbe, 24:703-716.e3, 2018; PubMed: 30439340; DOI: 10.1016/j.chom.2018.10.009

実験手法

X-RAY DIFFRACTION (2.9 Å)