6MDZ
Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2)
Summary for 6MDZ
Entry DOI | 10.2210/pdb6mdz/pdb |
Descriptor | Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3'), RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ... (4 entities in total) |
Functional Keywords | rna-binding protein, microrna, target directed microrna decay, hydrolase, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 223105.66 |
Authors | Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2018-09-05, release date: 2019-08-07, Last modification date: 2023-10-11) |
Primary citation | Sheu-Gruttadauria, J.,Pawlica, P.,Klum, S.M.,Wang, S.,Yario, T.A.,Schirle Oakdale, N.T.,Steitz, J.A.,MacRae, I.J. Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75:1243-1255.e7, 2019 Cited by PubMed: 31353209DOI: 10.1016/j.molcel.2019.06.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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