6MCP
L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A
Summary for 6MCP
Entry DOI | 10.2210/pdb6mcp/pdb |
Descriptor | LegK7, MOB kinase activator 1A, TETRAETHYLENE GLYCOL, ... (9 entities in total) |
Functional Keywords | translocated effector, ser/thr protein kinase, allosteric activation, hippo pathway, transferase |
Biological source | Legionella pneumophila subsp. pneumophila More |
Total number of polymer chains | 4 |
Total formula weight | 169021.95 |
Authors | Beyrakhova, K.A.,Xu, C.,Boniecki, M.T.,Cygler, M. (deposition date: 2018-09-01, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Lee, P.C.,Beyrakhova, K.,Xu, C.,Boniecki, M.T.,Lee, M.H.,Onu, C.J.,Grishin, A.M.,Machner, M.P.,Cygler, M. TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proc.Natl.Acad.Sci.USA, 117:14433-14443, 2020 Cited by PubMed: 32513747DOI: 10.1073/pnas.2000497117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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