6MAM

Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946

Summary for 6MAM

• Entry DOI: 10.2210/pdb6mam/pdb
• Descriptor: ADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ... (6 entities in total)
• Functional Keywords: ebola, ebolavirus, antibody, mab, fab, gp, glycoprotein, cleaved, monoclonal, broad, filovirus, marburg, ebov, bdbv, sudv, restv, tafv, marv, ravv, bundibugyo, sudan, human, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 264472.51

Authors

West, B.R.,Moyer, C.L.,Fusco, M.L.,Saphire, E.O. (deposition date: 2018-08-28, release date: 2019-03-20, Last modification date: 2023-10-11)

• Primary citation: West, B.R.,Wec, A.Z.,Moyer, C.L.,Fusco, M.L.,Ilinykh, P.A.,Huang, K.,Wirchnianski, A.S.,James, R.M.,Herbert, A.S.,Hui, S.,Goodwin, E.,Howell, K.A.,Kailasan, S.,Aman, M.J.,Walker, L.M.,Dye, J.M.,Bukreyev, A.,Chandran, K.,Saphire, E.O.; Structural basis of broad ebolavirus neutralization by a human survivor antibody.; Nat. Struct. Mol. Biol., 26:204-212, 2019; PubMed: 30833785; DOI: 10.1038/s41594-019-0191-4

Experimental method

X-RAY DIFFRACTION (4.1 Å)