6MAM

Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946

6MAM の概要

• エントリーDOI: 10.2210/pdb6mam/pdb
• 分子名称: ADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ... (6 entities in total)
• 機能のキーワード: ebola, ebolavirus, antibody, mab, fab, gp, glycoprotein, cleaved, monoclonal, broad, filovirus, marburg, ebov, bdbv, sudv, restv, tafv, marv, ravv, bundibugyo, sudan, human, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 264472.51

構造登録者

West, B.R.,Moyer, C.L.,Fusco, M.L.,Saphire, E.O. (登録日: 2018-08-28, 公開日: 2019-03-20, 最終更新日: 2023-10-11)

• 主引用文献: West, B.R.,Wec, A.Z.,Moyer, C.L.,Fusco, M.L.,Ilinykh, P.A.,Huang, K.,Wirchnianski, A.S.,James, R.M.,Herbert, A.S.,Hui, S.,Goodwin, E.,Howell, K.A.,Kailasan, S.,Aman, M.J.,Walker, L.M.,Dye, J.M.,Bukreyev, A.,Chandran, K.,Saphire, E.O.; Structural basis of broad ebolavirus neutralization by a human survivor antibody.; Nat. Struct. Mol. Biol., 26:204-212, 2019; PubMed: 30833785; DOI: 10.1038/s41594-019-0191-4

実験手法

X-RAY DIFFRACTION (4.1 Å)