6MA8

Human CYP3A4 bound to PMSF

Summary for 6MA8

DescriptorCytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (7 entities in total)
Functional Keywordsoxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, cyp3a4, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight57245.29
Authors
Sevrioukova, I.F. (deposition date: 2018-08-26, release date: 2019-01-16)
Primary citation
Sevrioukova, I.F.
Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules
Biochemistry, 2019
Experimental method
X-RAY DIFFRACTION (1.83 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23050 0.9% 8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6ma8
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Molmil generated image of 6ma8
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Molmil generated image of 6ma8
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More Biological unit images

Molmil generated image of 6ma8
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Molmil generated image of 6ma8
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Molmil generated image of 6ma8
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6ma8.pdb1.gz [341.73 KB])
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