6M9T

Crystal structure of EP3 receptor bound to misoprostol-FA

6M9T の概要

• エントリーDOI: 10.2210/pdb6m9t/pdb
• 分子名称: Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: gpcr, prostaglandin e2 receptor 3 (ep3), prostaglandin analogue, membrane protein, misoprostol-fa (biologically active free acid), xfel, lcp, t4l
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62262.59

構造登録者

Audet, M.,White, K.L.,Breton, B.,Zarzycka, B.,Han, G.W.,Lu, Y.,Gati, C.,Batyuk, A.,Popov, P.,Velasquez, J.,Manahan, D.,Hu, H.,Weierstall, U.,Liu, W.,Shui, W.,Katrich, V.,Cherezov, V.,Hanson, M.A.,Stevens, R.C. (登録日: 2018-08-24, 公開日: 2018-12-05, 最終更新日: 2023-10-11)

• 主引用文献: Audet, M.,White, K.L.,Breton, B.,Zarzycka, B.,Han, G.W.,Lu, Y.,Gati, C.,Batyuk, A.,Popov, P.,Velasquez, J.,Manahan, D.,Hu, H.,Weierstall, U.,Liu, W.,Shui, W.,Katritch, V.,Cherezov, V.,Hanson, M.A.,Stevens, R.C.; Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.; Nat. Chem. Biol., 15:11-17, 2019; PubMed: 30510194; DOI: 10.1038/s41589-018-0160-y

実験手法

X-RAY DIFFRACTION (2.5 Å)